Clinical Trials

Clinical trial participation is an individual, and important, decision. Clinical trials are designed to test new medications in people. Clinical trials may involve a placebo group (inactive ‘medicine’) to see if the new medication offers an advantage over current standard treatment. Some trials are ‘open label’, in which all participants receive active medications or experimental treatment.

There are many advantages to participating in clinical trials. Participants in clinical trials at a minimum receive current standard care for their disease from medical teams experienced with the disease. Clinical trials also offer the opportunity to try a new medication long before it is approved by the Food and Drug Administration.

If you choose to participate in a clinical trial, you have the right to understand fully what is expected of you, what the trial will involve and the potential risks to your health. You also have the right to withdraw your consent to participate at any time. Learn more about clinical trials, including those listed on this page, at www.clinicaltrials.gov.

The clinical trials listed here were verified as open and enrolling at the time the post was made, and are monitored periodically to ensure that the trial is still accepting participants. If a trial is no longer accepting patients, APFED may not be notified. If you find that registration has closed for a trial that is still listed on this page, please notify mail@apfed.org.

 

Trials That May be of Interest
Updated 7/14/17

Asthma

Study of Reslizumab in Patients With Uncontrolled Asthma and Elevated Blood Eosinophils

Ages: 12 years and older
Study Reference: NCT02452190
Study type: Interventional
Location: multiple, including international
Learn more

Eosinophilic Colitis (EC)

 

OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages
A project of:

cegir

Ages: 3-65
Study Reference: NCT02523118
Study type: Observational
Location: Multiple
Learn more

 


Eosinophilic Esophagitis (EoE)

 

A Placebo- Controlled Study in Adolescents and Adults With Eosinophilic Esophagitis (EoE) Measuring Histologic Response and Determine if Reduction in Dysphagia is Achieved

Ages: 11-55
Study Reference: NCT02605837
Study type: Interventional
Location: Arkansas, California, Florida, Louisiana

Visit website for additional information

A Prospective, Multicenter Study to Compare and Validate Endoscopic, Histologic, Molecular, and Patient-Reported Outcomes in Pediatric and Adult Patients With Eosinophilic Esophagitis (EoE), Gastritis (EG) and Colitis (EC)

Ages: 3-65
Study Reference: NCT02523118
Study type: Observational
Location: Multiple
Learn more

A Double, Blind Placebo-controlled, Randomized Trial to Study Efficacy and Safety of the Viaskin Milk for Treating Milk Induced Eosinophilic Esophagitis in Children

Ages: 4-17
Study Reference: NCT02579876
Study type: Interventional
Location: Philadelphia, PA
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A Randomized, Double-Blind, Parallel, Placebo-Controlled Study of the Efficacy, Safety and Tolerability of Dupilumab in Adult Patients With Active Eosinophilic Esophagitis

Ages: 18-50
Study Reference: NCT02379052
Study type: Interventional
Location: Multiple
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A Randomized, Double-blind, Placebo-controlled Study of the Use of Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis

Ages: 2-18
Study Reference: NCT02371941
Study type: Interventional
Location: Multiple
Learn more

a4b7 Integrin in Eosinophilic Esophagitis

Ages: 18+
Study Reference: NCT02546219
Study Type: Observational
Location:  Boston, MA
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Assessment of Esophageal Epithelium Integrity With Mucosal Impedance in Pediatric Patients

Ages: 1-18
Study Reference: NCT02320981
Study type: Observational
Location: Nashville, TN
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Budesonide Effervescent Tablet vs. Placebo in Active Eosinophilic Esophagitis

Ages: 18-75
Study Reference: NCT02434029
Study Type: Interventional
Location: Germany
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Budesonide Versus Fluticasone for Treatment of Eosinophilic Esophagitis

Ages: 16-80
Study Reference: NCT02019758
Study type: Interventional
Location: Chapel Hill, NC
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Cytosponge and Dietary Therapy in EoE

Ages:  18-70
Study Reference: NCT02599558
Study Type:  Interventional
Location:  Minnesota
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Cytosponge Protocol

Ages: 18-65
Study Reference: NCT01585103
Study type: Interventional
Location: Mayo Clinic, Rochester MN
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Efficacy of Allergy Patch Testing in Directed Dietary Therapy of Eosinophilic Esophagitis: A Pilot Study

Ages: 18-90
Study Reference: NCT02227836
Study type: Interventional
Location: Mayo Clinic, Rochester, MI
Learn more

Eosinophilic Esophagitis (EoE) Intervention Trial-Randomized 1 Food Elimination vs. 4 Food Elimination Diet followed by Swallowed Glucocorticoids
A project of:

cegir

Ages: 6-17
Study Reference: NCT02610816
Study type: Interventional
Location: Multiple
Learn more

Esophageal Absorption in Eosinophilic Esophagitis

Ages: 18-80
Study Reference: NCT02314455
Study type: Interventional
Location: Mayo Clinic, Rochester, MI
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Phase 2 Study of Esophageal String Test in Eosinophilic Esophagitis

Ages: 7-65
Study Reference: NCT02008903
Study type: Observational
Location: Children’s Hospital Colorado (Aurora, CO); Lurie Children’s Hospital (Chicago, IL); Northwestern University (Chicago, IL)
Learn more

Eosinophilic Esophagitis Clinical Therapy Trial

Ages: 3-17
Study Reference: NCT01821898
Study type: Interventional
Location: Texas Children’s Hospital, Houston, TX
Learn more

Eosinophilic Esophagitis (EoE) Intervention Trial-Randomized 1 Food Elimination vs. 4 Food Elimination Diet Followed by Swallowed Glucocorticoids

Ages: 6-17
Study Reference: NCT02610816
Study type: Interventional
Location: Arkansas, California, Colorado, Illinois, Indiana, Massachusetts, New York, North Carolina, Ohio, Pennsylvania
Learn more

Website for additional details

An Extension Study to Evaluate Maintenance of Efficacy and Long-term Treatment Effect of Oral Budesonide Suspension (OBS) in Adults and Adolescents With Eosinophilic Esophagitis (EoE) (ORBIT2)

Ages: 11-55
Study Reference: NCT02736409
Study type: Interventional
Location: North Little Rock, AR

Visit website for additional information

Fibrostenotic Eosinophilic Esophagitis: Endoscopic, Histologic and Molecular Characterization and Evaluation of Clinical Assessment Tools

Ages: 5-80
Study Reference: NCT02453126
Study type: Observational
Location: Mayo Clinic, Rochester, MI
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FLUTicasone in Eosinophilic Esophagitis (FLUTE): A Randomized, Double-blind, Placebo-controlled, Dose-ranging, and Maintenance Study of APT-1011 in Subjects With Eosinophilic Esophagitis

Ages: ≥18 years of age
Study Reference: NCT03191864
Study Type: Interventional
Location: Multiple
Learn more  
Find out if you are eligible

Expanding the Clinical Applications of Functional Luminal Imaging (EndoFLIP) in Esophageal Stenoses

Ages: 18-80
Study Reference: NCT02354716
Study type: Observational
Location: Philadelphia, PA
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Molecular Basis of Food Allergy

Ages: 4 months-75 years
Study Reference: NCT01832324
Study type: Observational
Location: Children’s Hospital of Philadelphia
Learn more

Mucosal Impedance and Eosinophilic Esophagitis

Ages: 18-90
Study Reference: NCT01953575
Study type: Interventional
Location: Mayo Clinic, Rochester MN
Learn more

Nasal Nitric Oxide Levels in EoE

Ages: 18+
Study Reference: NCT01929824
Study type: Observational
Location: Mayo Clinic, Rochester MN
Learn more

Natural History and Genetics of Food Allergy and Related Conditions

Ages: 2-99
Study Reference: NCT02504853
Study Type: Observational
Location: Maryland
Learn more

OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages
A project of:

cegir

Ages: 3-65
Study Reference: NCT02523118
Study type: Observational
Location: Multiple
Learn more

Pilot Study for Imaging of the Esophagus Using an OFDI Capsule

Ages: 16+
Study Reference: NCT02204150
Study type: Interventional
Location: Boston, MA
Learn more

Pilot Study to Image the Esophagus Using Spectrally Encoded Confocal Microscopy (SECM)

Ages: 14+
Study Reference: NCT02202590
Study type: Interventional
Location: Boston, MA
Learn more

Protocol for Food Antigen Staining in Esophageal Mucosa in Patients With Eosinophilic Esophagitis

Ages: 18-80
Study Reference: NCT02434705 
Study type: Interventional
Location: Mayo Clinic, Rochester, MI
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SOFEED: Six Food vs. One Food Eosinophilic Esophagitis Diet Study
A project of:

cegir

Ages: 18-60
Study Reference: NCT02778867
Study type: Interventional
Location: Multiple
Learn more


Eosinophilic Fasciitis (EF)

Coordination of Rare Diseases at Sanford

Ages: not specified
Study Reference: NCT01793168
Study type: Observational
Location: Sioux Falls, SD
Learn more


Eosinophilic Gastroenteritis (EGE)

Data and Sample Collection Study to Elucidate the Mechanisms of Eosinophilic Disorders

Ages: consent obtained for ages 11+
Study Reference: NCT00267501
Study type: Observational
Location: Cincinnati, OH
Learn more

Effect of Elemental Diet on Adult Patients with Eosinophilic Gastroenteritis and Eosinophilic Gastrisis (ELEMENT)
A project of:

cegir
Ages: 18-65
Study Reference:
Study type: Observational
Location: Chicago, IL
Learn more

 


Eosinophilic Gastritis (EG)

A Prospective, Multicenter Study to Compare and Validate Endoscopic, Histologic, Molecular, and Patient-Reported Outcomes in Pediatric and Adult Patients With Eosinophilic Esophagitis (EoE), Gastritis (EG) and Colitis (EC)

Ages: 3-65
Study Reference: NCT02523118
Study type: Observational
Location: Multiple
Learn more

Effect of Elemental Diet on Adult Patients with Eosinophilic Gastroenteritis and Eosinophilic Gastrisis (ELEMENT)
A project of:

cegir
Ages: 18-65
Study Reference:
Study type: Observational
Location: Chicago, IL
Learn more

OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages
A project of:

cegir

Ages: 3-65
Study Reference: NCT02523118
Study type: Observational
Location: Multiple
Learn more


Eosinophilic Granulomatosis With Polyangitis (Churg Strauss Syndrome)

Chronic Childhood Vasculitis: Characterizing the Individual Rare Diseases to Improve Patient Outcomes

Ages: 0-20
Study Reference: NCT02006134
Study type: Observational
Location: Multiple, including international
Learn more

High Dose Immune Suppression With Hematopoietic Stem Cell Support in Refractory Vasculitis, Necrotizing Vasculitis, Neurovascular Behcet’s Disease, and Sjogren’s Syndrome

Ages: 16-60
Study Reference: NCT00278512
Study type: Interventional
Location: Chicago, IL
Learn more

Longitudinal Protocol for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)

Ages: any age
Study Reference: NCT00315380
Study type: Observational
Location: Multiple, including Canada
Learn more

Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener’s Granulomatosis)

Ages: 18+
Study Reference: NCT01862068
Study Type: Observational
Location: France
Learn more

Vasculitis Pregnancy Registry

Ages: 18-50 Female
Study Reference: NCT02593565
Study Type:  Observational/Patient Registry
Location:  Online Registry
Learn more

VCRC Genetic Repository One-Time DNA Protocol

Ages: 7+
Study Reference: NCT01241305
Study type: Observational
Location: Multiple, including Canada
Learn more


HES (Hypereosinophilic Syndrome)

Efficacy and Safety Study of Mepolizumab in Subjects With Severe Hypereosinophilic Syndrome (HES)

Ages: 12+
Study Reference: NCT02836496
Study type: Interventional
Location: Multiple, including international sites
Learn more

A Compassionate Use Open-Label Study of Anti IL-5 (Mepolizumab) Treatment in Subjects With Hypereosinophilic Syndrome

Ages: 12+
Study Reference: NCT00244686
Study type: Interventional
Location: Multiple, including international sites
Learn more

A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression

Ages: any age
Study Reference: NCT00091871
Study type: Observational
Location: Bethesda, MD
Learn more

A Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Subcutaneous Benralizumab (MEDI-563) in Reducing Eosinophilia in Subjects With Hypereosinophilic Syndrome (HES)

Ages: 18-65
Study Reference: NCT02130882
Study type: Interventional
Location: Bethesda, MD
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An Open-Label, Proof-of-Concept Study to Evaluate the Safety and Efficacy of Dexpramipexole (KNS-760704) in Subjects With Hypereosinophilic Syndrome

Ages: 18+
Study Reference: NCT02101138
Study type: Interventional
Location: Bethesda, MD
Learn more

Assessment of Glucocorticoid Responsiveness and Mechanisms of Resistance in Hypereosinophilic Syndromes

Ages: 7+
Study Reference: NCT01524536
Study type: Interventional
Location: Bethesda, MD
Learn more

Efficacy of Imatinib Mesylate in Reducing Eosinophilia in Patients With Myeloproliferative and/or Steroid-Refractory Hypereosinophilic Syndrome

Ages: 2+
Study Reference: NCT00044304
Study type: Interventional
Location: Bethesda, MD
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Identification of New Markers in the Hypereosinophilic Syndrome

Ages: 18-80
Study Reference: NCT01713504
Study type: Interventional
Location: Lille, Nord, France
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SL-401 in Advanced, High Risk Myeloproliferative Neoplasms (Systemic Mastocytosis, Advanced Symptomatic Hypereosinoophic Disorder, Myelofibrosis, Chronic Myelomonocytic Leukemia)

Ages: 18+
Study Reference: NCT02268253
Study Type: Interventional
Location: Multiple US/Canada
Learn more 


Vasculitis

One-Time DNA Study for Vasculitis

Study Reference: NCT01241305
Location: Please view the link below for the complete list of locations.
Learn more

Vasculitis Pregnancy Registry

Ages: 18-50 Female
Study Reference: NCT02593565
Study Type:  Observational/Patient Registry
Location:  Online Registry
Learn more