Clinical Trials

About Clinical Trials
Clinical trial participation is an individual, and important, decision. There are many advantages to participating in a trial, including care from medical teams experienced with the disease and the opportunity to try a new medication long before it is approved by the Food and Drug Administration to treat an indicated condition. If you choose to participate in a clinical trial, you have the right to understand fully what is expected of you, what the trial will involve and the potential risks to your health. You also have the right to withdraw your consent to participate at any time. For more resources about trial participation and informed consent, please see the resources available from the U.S. Department of Health and Human Services.

Please note: Trials that are recruiting patients with eosinophil-associated disease and a search engine that can help match you to an enrolling trial appear below.  Neither the list nor search engine results are considered exhaustive. The clinical trials listed here were verified as open and enrolling at the time the post was made, and are monitored periodically to ensure that the trial is still accepting participants. If a trial is no longer accepting patients, APFED may not be notified. If you find registration has closed for a trial that is still listed on this page, please notify mail@apfed.org.

Trials of Interest:

Eosinophilic Esophagitis

A Study of Lirentelimab (AK002) in Patients With Active Eosinophilic Esophagitis (KRYPTOS)

Allakos

Ages: 12-80
Study Reference: NCT04322708
Study type: Interventional
Location: Multiple
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A Phase 3, Randomized, 3-Part Study to Investigate the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients With Eosinophilic Esophagitis (EoE)

Ages: 12 and older
Study Reference: NCT03633617
Study type: Interventional
Location: Multiple
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Cytosponge and Dietary Therapy in EoE

Ages:  18-70
Study Reference: NCT02599558
Study Type:  Interventional
Location:  Minnesota
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Cytosponge Protocol

Ages: 18-65
Study Reference: NCT01585103
Study type: Interventional
Location: Mayo Clinic, Rochester MN
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Phase 2 Study of Esophageal String Test in Eosinophilic Esophagitis

Ages: 7-65
Study Reference: NCT02008903
Study type: Observational
Location: Children’s Hospital Colorado (Aurora, CO); Lurie Children’s Hospital (Chicago, IL); Northwestern University (Chicago, IL)
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Eosinophilic Esophagitis (EoE) Intervention Trial-Randomized 1 Food Elimination vs. 4 Food Elimination Diet Followed by Swallowed Glucocorticoids

Ages: 6-17
Study Reference: NCT02610816
Study type: Interventional
Location: Arkansas, California, Colorado, Illinois, Indiana, Massachusetts, New York, North Carolina, Ohio, Pennsylvania
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Website for additional details

Fibrostenotic Eosinophilic Esophagitis: Endoscopic, Histologic and Molecular Characterization and Evaluation of Clinical Assessment Tools

Ages: 5-80
Study Reference: NCT02453126
Study type: Observational
Location: Mayo Clinic, Rochester, MI
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FLUTicasone in Eosinophilic Esophagitis (FLUTE): A Randomized, Double-blind, Placebo-controlled, Dose-ranging, and Maintenance Study of APT-1011 in Subjects With Eosinophilic Esophagitis

Ages: ≥18 years of age
Study Reference: NCT03191864
Study Type: Interventional
Location: Multiple
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Find out if you are eligible

Molecular Basis of Food Allergy

Ages: 4 months-75 years
Study Reference: NCT01832324
Study type: Observational
Location: Children’s Hospital of Philadelphia
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Natural History and Genetics of Food Allergy and Related Conditions

Ages: 2-99
Study Reference: NCT02504853
Study Type: Observational
Location: Maryland
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Pilot Study to Image the Esophagus Using Spectrally Encoded Confocal Microscopy (SECM)

Ages: 14+
Study Reference: NCT02202590
Study type: Interventional
Location: Boston, MA
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Protocol for Food Antigen Staining in Esophageal Mucosa in Patients With Eosinophilic Esophagitis

Ages: 18-80
Study Reference: NCT02434705
Study type: Interventional
Location: Mayo Clinic, Rochester, MI
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Eosinophilic Gastritis/Eosinophilic Gastroenteritis/Eosinophilic Duodenitis

A Study to Assess AK002 in Eosinophilic Gastritis and/or Eosinophilic Duodenitis (Formerly Referred to as Eosinophilic Gastroenteritis) (ENIGMA 2)

Allakos

Ages: 18-80
Study Reference: NCT04322604
Study type: Interventional
Location: Multiple locations in the U.S.
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Download the flyer

Benralizumab for Eosinophilic Gastritis (ANTI-IL5RA)

Ages: 12-60
Study Reference: NCT03473977
Study type: Interventional
Location: Children's Hospital Medical Center, Cincinnati

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       Patient brochure with study information

Data and Sample Collection Study to Elucidate the Mechanisms of Eosinophilic Disorders

Ages: consent obtained for ages 11+
Study Reference: NCT00267501
Study type: Observational
Location: Cincinnati, OH
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Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome)

Chronic Childhood Vasculitis: Characterizing the Individual Rare Diseases to Improve Patient Outcomes

Ages: 0-20
Study Reference: NCT02006134
Study type: Observational
Location: Multiple, including international
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High Dose Immune Suppression With Hematopoietic Stem Cell Support in Refractory Vasculitis, Necrotizing Vasculitis, Neurovascular Behcet's Disease, and Sjogren's Syndrome

Ages: 16-60
Study Reference: NCT00278512
Study type: Interventional
Location: Chicago, IL
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Longitudinal Protocol for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)

Ages: any age
Study Reference: NCT00315380
Study type: Observational
Location: Multiple, including Canada
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Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)

Ages: 18+
Study Reference: NCT01862068
Study Type: Observational
Location: France
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Vasculitis Pregnancy Registry

Ages: 18-50 Female
Study Reference: NCT02593565
Study Type:  Observational/Patient Registry
Location:  Online Registry
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VCRC Genetic Repository One-Time DNA Protocol

Ages: 7+
Study Reference: NCT01241305
Study type: Observational
Location: Multiple, including Canada
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Hypereosinophilic Syndromes

A Multi-center, Open-label Extension, Safety Study of Mepolizumab in Subjects With Hypereosinophilic Syndrome (HES) From Study 200622

Ages: 12+
Study Reference: NCT03306043
Study type: Interventional
Location: Multiple,  international
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Efficacy and Safety Study of Mepolizumab in Subjects With Severe Hypereosinophilic Syndrome (HES)

Ages: 12+
Study Reference: NCT02836496
Study type: Interventional
Location: Multiple, including international sites
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Study to Evaluate Safety and Efficacy of Benralizumab in Subjects With Hypereosinophilic Syndrome

Ages: 18-65
Study Reference: NCT02130882
Study type: Interventional
Location: Bethesda, MD
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A Compassionate Use Open-Label Study of Anti IL-5 (Mepolizumab) Treatment in Subjects With Hypereosinophilic Syndrome

Ages: 12+
Study Reference: NCT00244686
Study type: Interventional
Location: Multiple, including international sites
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A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression

Ages: any age
Study Reference: NCT00091871
Study type: Observational
Location: Bethesda, MD
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Assessment of Glucocorticoid Responsiveness and Mechanisms of Resistance in Hypereosinophilic Syndromes

Ages: 7+
Study Reference: NCT01524536
Study type: Interventional
Location: Bethesda, MD
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Efficacy of Imatinib Mesylate in Reducing Eosinophilia in Patients With Myeloproliferative and/or Steroid-Refractory Hypereosinophilic Syndrome

Ages: 2+
Study Reference: NCT00044304
Study type: Interventional
Location: Bethesda, MD
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SL-401 in Advanced, High Risk Myeloproliferative Neoplasms (Systemic Mastocytosis, Advanced Symptomatic Hypereosinoophic Disorder, Myelofibrosis, Chronic Myelomonocytic Leukemia)

Ages: 18+
Study Reference: NCT02268253
Study Type: Interventional
Location: Multiple US/Canada
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Eosinophilic Fasciitis

Coordination of Rare Diseases at Sanford

Ages: not specified
Study Reference: NCT01793168
Study type: Observational
Location: Sioux Falls, SD
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