Eosinophilic Gastroenteritis Quick Facts

Eosinophilic Gastroenteritis (EGE)

Eosinophilic gastroenteritis is a rare disease in which a type of white blood cell, the eosinophil, causes injury and inflammation to the stomach and the small intestine. Eosinophilic gastroenteritis may affect both adults and children. The cause is unknown.


  • Vomiting, nausea, diarrhea
  • Difficulty feeding and/or gaining weight
  • Poor growth and weight loss
  • Abdominal pain
  • Bloody diarrhea
  • Malnutrition
  • Fatigue

Associated Diseases:

  • Environmental and/or food allergies in some
  • May occur in conjunction with other EGIDs


  • Unknown
  • Food allergies may play a role in some patients


  • Upper endoscopy (placement of a lighted tube into the mouth, esophagus and stomach)
  • Biopsies of the large intestine are necessary to make the diagnosis. Eosinophils causing injury on biopsy, in the context of symptoms consistent with EC


  • Endoscopy may show erosions, ulcers or irritated areas of the large intestine
  • Biopsy: Eosinophils invading the large intestine. Biopsy may show chronic inflammation. No consensus recommendations on definition or diagnosis.
Allergy Testing

  • Allergy testing may be helpful in some patients to identify and remove offending food allergens.


  • Avoid known food allergens or triggers
  • Systemic Steroids (prednisone)
  • Elemental diet (avoid all food protein and obtain all nutrition from a special formula)
  • Iron supplementation if iron deficient
  • Nutritional support as needed
  • Anti-inflammatory medications for the large intestine


  • Depends on response to treatment
  • Recurrent episodes may occur

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Author: Wendy Book MD, updated 9-08-2011, reviewed by Dr. Jonathan Markowitz
© American Partnership for Eosinophilic Disorders 2011. Content may not be reproduced in part or in whole without express written consent from APFED. Contact us